Summary: In older Spanish adults with overweight/obesity and metabolic syndrome, a Mediterranean Diet and lifestyle intervention significantly improved perceived vitality, physical and mental well-being, and nutritional self-efficacy compared to usual behaviours lacking structured dietary or lifestyle intervention, though it was associated with barriers including low motivation, disease burden, mobility issues, and limited social support. PICO Description Population Spanish adults aged 60–81 years with overweight or obesity and diagnosed with metabolic syndrome participating in a randomized clinical trial. Intervention Mediterranean Diet and healthy lifestyle behavioural intervention supported by continuous contact with researchers, peer support, and nutritional education. Comparison Usual lifestyle practices…
Author: FWA
Summary: In Chinese middle-aged and elderly adults with prediabetes or early diabetes, purified anthocyanin supplementation (160, 320, and 640 mg/day for 12 weeks) showed no significant improvement compared to placebo, and it was not associated with adverse effects. PICO Description Population Chinese middle-aged and elderly adults (n=184) with prediabetes or early-stage diabetes (dysglycemia). Intervention Daily supplementation with purified anthocyanins at doses of 160 mg, 320 mg, or 640 mg for 12 weeks. Comparison Placebo group receiving no active anthocyanin supplementation. Outcome No significant changes or dose-response effects in arterial stiffness (measured by baPWV), blood pressure, ABI, or composite cardiovascular risk…
Summary: In adults with newly diagnosed type 2 diabetes mellitus, short-term intensive insulin therapy (SIIT) combined with metformin and pioglitazone or sitagliptin significantly improved glycemic control, reduced insulin requirements, and enhanced β-cell function during treatment compared to SIIT alone via continuous subcutaneous insulin infusion (CSII), though it was associated with no significant difference in 12-month diabetes remission rates. PICO Description Population Adults with newly diagnosed type 2 diabetes mellitus and a mean HbA1c of 10.6% ± 2.2%. Intervention Short-term intensive insulin therapy (SIIT) using CSII plus either 90-day oral metformin and pioglitazone (CSII + Met + Pio) or sitagliptin (CSII…
Summary: In postmenopausal women with overweight or obesity, high-dose green tea extract (GTE) supplementation (843 ± 44 mg EGCG/day) did not significantly reduce inflammatory cytokines compared to placebo over a 12-month period, and it was not associated with notable side effects. PICO Description Population Postmenopausal women with overweight or obesity, participating in the Minnesota Green Tea Trial (n = 97). Intervention Daily supplementation with high-dose green tea extract containing 843 ± 44 mg epigallocatechin gallate (EGCG) for 12 months. Comparison Placebo group receiving an identical capsule without active ingredients for the same duration. Outcome No statistically significant differences were observed…
Summary: In Chinese middle-aged and elderly adults with prediabetes or early diabetes, purified anthocyanins supplementation (160, 320, 640 mg/day) did not significantly improve arterial stiffness or cardiovascular risk factors compared to placebo, and was not associated with notable side effects. PICO Description Population Chinese middle-aged and elderly adults with prediabetes or early-stage diabetes (dysglycemia). Intervention Daily supplementation with purified anthocyanins at doses of 160 mg, 320 mg, and 640 mg over a 12-week period. Comparison Placebo control group receiving no active anthocyanins. Outcome No statistically significant improvements in arterial stiffness (measured by baPWV), ankle-brachial index, four-limb blood pressures, or composite…
Summary: In adults with diabetes, individualized HbA1c target-setting (5 mmol/mol higher or lower than current HbA1c) did not significantly impact glycaemic outcomes or patient-reported measures compared to alternate target assignment group, though it was associated with high acceptability and improvements in diabetes distress and self-efficacy. PICO Description Population Adults with diabetes participating in a randomised feasibility trial evaluating HbA1c target-setting. Intervention Explicit HbA1c targets set to 5 mmol/mol below participants’ baseline HbA1c levels (Group B). Comparison HbA1c targets set 5 mmol/mol above participants’ baseline HbA1c levels (Group A). Outcome No significant between-group differences were found in HbA1c or psychometric outcomes.…
Summary: In obese women aged 50–80 years with knee osteoarthritis, therapeutic exercise performed in a sitting position significantly reduced pain, improved knee function, and enhanced physical quality of life compared to similar exercises performed in a standing position, though it was associated with less improvement in mental quality of life. PICO Description Population Fifty-four obese women aged 50–80 years diagnosed with knee osteoarthritis. Intervention A 12-week therapeutic exercise program conducted in the sitting position, including aerobics, hip stretching and strengthening, and balance training (45-minute sessions, three times weekly, increasing by 30 minutes every four weeks). Comparison An identical 12-week therapeutic…
Summary: In patients with diabetic nephropathy (DN), treatment with Suyin Detoxification Prescription (SDP) significantly reduced serum creatinine levels and proteinuria compared to standard care or untreated controls, though it was associated with no significant adverse effects reported. PICO Description Population Patients diagnosed with diabetic nephropathy (DN), characterized by progressive renal dysfunction and chronic proteinuria. Intervention Suyin Detoxification Prescription (SDP), a traditional Chinese medicine formula, administered as part of a randomized controlled trial and validated through network pharmacology and molecular assays. Comparison Standard care for DN or untreated diabetic nephropathy model mice; comparisons also included FXR knockout models to validate pathway…
Summary: In adults with type 1 diabetes (T1D), a short-term online educational program significantly reduced diabetes stigma, improved body image, and enhanced body image coping strategies compared to standard care with no intervention, though it was associated with no reported adverse effects. PICO Description Population Adults diagnosed with type 1 diabetes (T1D), recruited using convenience sampling, totaling 88 individuals. Intervention Participation in four online educational sessions focusing on diabetes stigma, body image, and coping strategies. Comparison Control group receiving standard care without any additional educational intervention. Outcome The intervention group had significantly lower posttest DSAS-1 scores (reduced stigma), lower BIS…
Summary: In children and adults with type 1 diabetes (T1D), automated insulin delivery (AID) using MiniMed™ 670G or 770G systems significantly improved HbA1c and reduced time spent in hypoglycemia compared to multiple daily injections (MDI) with or without continuous glucose monitoring, though it was associated with no major increase in severe hypoglycemia or diabetic ketoacidosis rates. PICO Description Population Children and adults aged 2–80 years diagnosed with type 1 diabetes, classified into two subgroups based on baseline HbA1c levels (>8.0% and ≤8.0%), across 32 international centers. Intervention Automated insulin delivery (AID) using MiniMed™ 670G or 770G insulin pump systems over…