Summary:
In obese adults, gallic acid supplementation (200 mg/day) combined with physical training significantly reduced waist circumference, waist-to-hip ratio, and skinfold thickness, with trends toward increased fat-free mass and improved albumin levels compared to placebo and/or no exercise, though it was associated with no reported adverse effects.
| PICO | Description |
|---|---|
| Population | Adults classified as eutrophic or obese, stratified into trained and untrained groups for a 12-week randomized, double-blind, placebo-controlled clinical trial. |
| Intervention | Oral supplementation of gallic acid at 200 mg/day in combination with a structured physical training regimen over 12 weeks. |
| Comparison | Placebo supplementation with or without physical training; comparisons made across eight groups stratified by nutritional status, training, and supplementation. |
| Outcome | Significant reductions in waist-to-hip ratio (p = 0.031), waist circumference (p = 0.041), and skinfold thickness (pectoral p = 0.044; abdominal p = 0.036). A trend toward increased fat-free mass (p = 0.054) and significantly higher serum albumin concentrations (p = 0.043) was observed in the obese group receiving both gallic acid and physical training. |
Source: Barbosa, Bruna Kaicy, et al. “Combined Effects of Gallic Acid Supplementation and Physical Training on Body Composition and Biochemical Parameters in Obese Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.” Read article here.
