Summary:
In adults without diabetes more than one year following sleeve gastrectomy (SG), consumption of a moderate, fat-dominant preload (28 g Brazil nuts) did not significantly alter postprandial nadir glucose or overall glycaemic excursion compared to a water preload (100 mL), though it was associated with higher peak insulin concentrations and elevated pre-meal GLP-1 levels.
| PICO | Description |
|---|---|
| Population | Ten adults without diabetes, more than one year post-sleeve gastrectomy (SG), undergoing mixed-meal tolerance tests. |
| Intervention | Preload of 28 g Brazil nuts (moderate, fat-dominant meal) consumed 30 minutes prior to the mixed meal. |
| Comparison | Control condition with 100 mL water consumed 30 minutes before the mixed meal. |
| Outcome | Nadir plasma glucose was identical between conditions (3.8 mmol/L; p = 0.849). No differences were observed in peak or overall postprandial glucose (iAUC₀–₁₈₀ min). However, preload increased pre-meal insulin, c-peptide, and GLP-1 levels (all p < 0.05), and resulted in significantly higher peak insulin and c-peptide post-meal values. Symptom ratings for hypoglycaemia and dumping were similar across conditions. |
Source: Whelehan, Gráinne, et al. “The Impact of a Fat-Dominant Preload Before a Carbohydrate-Rich Meal on Glucose Homeostasis in Patients Without Diabetes After Sleeve Gastrectomy: A Proof-of-Concept, Randomised, Open-Label, Crossover Study.” Read article here.
