Summary:
In patients undergoing total thyroidectomy with central neck dissection for differentiated thyroid carcinoma, intraoperative ischemic preconditioning of the parathyroid glands (IPCP) did not significantly reduce postoperative hypoparathyroidism compared to standard surgery without preconditioning, though it was associated with a higher rate of early parathyroid function recovery, which warrants further investigation.
| PICO | Description |
|---|---|
| Population | Patients (n = 135) undergoing total thyroidectomy with central neck dissection for differentiated thyroid carcinoma at a single center. |
| Intervention | Intraoperative ischemic preconditioning of the parathyroid glands (IPCP), performed by three cycles of 60-second arterial occlusion followed by 60-second reperfusion. |
| Comparison | Standard surgical procedure without ischemic preconditioning, serving as the control group. |
| Outcome | IPCP did not significantly reduce postoperative hypoparathyroidism (50.8% vs 41.2%, p = 0.265) or protracted hypoparathyroidism (6.0% vs 14.7%, p = 0.096). However, exploratory analysis showed significantly higher rates of early parathyroid function recovery in the IPCP group (88.2% vs 64.3%, p = 0.025). Other outcomes, such as hypocalcemia and surgical complications, were comparable between groups. |
Source: Sheng, Qixuan, et al. “A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.” Read article here.
