Summary:
In women aged 18–45 years with overweight and class I obesity (BMI 25.5–35), an energy-restricted Mediterranean-type ketogenic diet (KD) significantly altered amino acid metabolism, increasing α-aminobutyric acid and BCAAs, while reducing alanine, methionine, threonine, and tryptophan levels compared to a standard isocaloric diet, though it was associated with higher urinary excretion of BCAAs and β-aminoisobutyric acid.
| PICO | Description |
|---|---|
| Population | Women aged 18–45 years with a BMI of 25.5–35 kg/m² (overweight or class I obesity), without chronic diseases. |
| Intervention | Eight-week, energy-restricted, Mediterranean-type ketogenic diet (~1750 kcal/day) provided via food catering, aiming to modulate protein and amino acid metabolism. |
| Comparison | Standard isocaloric diet (~1750 kcal/day) over eight weeks, also provided through food catering. |
| Outcome | Ketogenic diet was associated with significant changes in amino acid metabolism including increased serum α-aminobutyric acid and BCAAs, decreased alanine, methionine, threonine, tryptophan, and reduced urinary amino acid excretion overall, but elevated urinary BCAA and β-aminoisobutyric acid levels. These changes may reflect impacts on inflammation, oxidative stress, and cardiometabolic risk. |
Source: Natalia Drabińska-Fois, et al. “Alteration in Amino Acid Metabolism After Isocaloric, Energy-Restricted Ketogenic Diet in Women with Overweight and Obesity: Randomized KETO-MINOX Trial.” Read article here.
