Summary:
In young children aged 2–6 years with overweight or obesity, a parent-based lifestyle support intervention significantly reduced BMI, BMI z-score, and energy/macronutrient intake compared to standard care, though it was associated with no direct side effects reported; response varied by AMY1 gene copy number.
| PICO | Description |
|---|---|
| Population | Children aged 2–6 years classified as overweight or obese, participating in a 9-month lifestyle intervention study examining the relationship between salivary AMY1 gene copy number, BMI z-score, and dietary intake. |
| Intervention | Parent-based support lifestyle intervention designed to improve children’s nutrition and reduce BMI through behavioral and dietary modifications. |
| Comparison | Standard care group receiving general healthcare advice without structured parental involvement or targeted lifestyle support. |
| Outcome | The intervention group showed greater reductions in BMI, BMI z-score, and energy/macronutrient intake compared to standard care. Higher AMY1 gene copy number correlated with increased carbohydrate intake and BMI z-score at baseline, and was associated with greater reductions in polyunsaturated fat intake post-intervention, though no direct link was found between AMY1 CN and BMI z-score changes. |
Source: Margalida Monserrat-Mesquida, et al. “Salivary Amylase Gene Copy Number Relates with BMI Z-Score and with Response to Lifestyle Intervention for Children with Overweight and Obesity.” Read article here.
