Structured Summary:
In Japanese patients with type 2 diabetes, having a history of treatment dropout and HbA1c levels ≥10% significantly increased the risk of subsequent dropout compared to patients without a treatment dropout history or lower HbA1c levels, though it was associated with no major clinical safety concerns.
| PICO | Description |
|---|---|
| Population | Japanese patients with type 2 diabetes who participated in the J-DOIT2-LT008 trial. |
| Intervention | Patients with a history of treatment dropout and HbA1c levels of ≥10%. |
| Comparison | Patients without a history of dropout and HbA1c levels under 10%. |
| Outcome | A history of treatment dropout was strongly associated with a higher subsequent dropout risk. High HbA1c levels (≥10%) also predicted dropout risk in patients without prior dropout history. These findings highlight potential indicators for tailored interventions to enhance treatment adherence. |
Source: Goto, Atsushi, et al. “Association of dropout history and HbA1c levels with subsequent dropout risk in patients with diabetes: a secondary analysis of the Japan Diabetes Outcome Intervention Trial-2 Large-Scale Trial 008 (J-DOIT2-LT008).” Read article here.
