Summary:
In pregnant individuals categorized by metabolic health status (metabolically unhealthy obese – MUO vs. metabolically healthy obese – MHO), intensive behavioral therapy (IBT) for gestational weight gain (GWG) significantly reduced GWG in the MUO group compared to the MHO group,
though it was associated with a higher incidence of gestational diabetes and increased infant adiposity in the MUO group.
| PICO | Description |
|---|---|
| Population | Pregnant individuals classified as metabolically unhealthy obese (MUO) versus metabolically healthy obese (MHO). |
| Intervention | Intensive behavioral therapy (IBT) targeting gestational weight gain (GWG). |
| Comparison | Outcomes assessed between the MUO group and the MHO group during pregnancy. |
| Outcome | MUO individuals experienced less gestational weight gain compared to the MHO group; however, they exhibited a higher incidence of gestational diabetes and infants with a higher proportion of adiposity. The maternal metabolic health phenotype significantly affected adverse maternal and infant outcomes beyond GWG interventions. |
Source: Emily W. Flanagan, et al. “Metabolic Health and Heterogeneous Outcomes of Prenatal Interventions: A Secondary Analysis of a Randomized Clinical Trial.” Read article here.
