Summary:
In individuals with parental antenatal corticosteroid exposure, this exposure significantly influenced endocrine and metabolic changes in the second generation (F2) compared to those with no corticosteroid exposure, though it was associated with potential risks in growth and metabolic health.
| PICO | Description |
|---|---|
| Population | Second-generation individuals (F2) born to parents exposed to antenatal corticosteroids in utero. |
| Intervention | Exposure to antenatal corticosteroids administered to parents who were at risk of preterm birth. |
| Comparison | Second-generation individuals (F2) without parental antenatal corticosteroid exposure. |
| Outcome | Parental antenatal corticosteroid exposure resulted in detectable endocrine and metabolic changes in the second generation (F2), including potential alterations to growth and metabolic health. This highlights the intergenerational effects associated with corticosteroid exposure. |
Source: Libby G. Lord, et al. “Second Generation Effects of Antenatal Corticosteroid Exposure: 50-Year Follow-Up of the Auckland Steroid Trial.” Read article here.
