Summary:
In patients with diabetic nephropathy (DN), treatment with Suyin Detoxification Prescription (SDP) significantly reduced serum creatinine levels and proteinuria compared to standard care or untreated controls, though it was associated with no significant adverse effects reported.
| PICO | Description |
|---|---|
| Population | Patients diagnosed with diabetic nephropathy (DN), characterized by progressive renal dysfunction and chronic proteinuria. |
| Intervention | Suyin Detoxification Prescription (SDP), a traditional Chinese medicine formula, administered as part of a randomized controlled trial and validated through network pharmacology and molecular assays. |
| Comparison | Standard care for DN or untreated diabetic nephropathy model mice; comparisons also included FXR knockout models to validate pathway specificity. |
| Outcome | SDP resulted in significant reductions in serum creatinine (p = 0.009) and proteinuria (p = 0.03), downregulation of proinflammatory markers (TNF-α, gp91, P-MLK1), and protective effects reversed in FXR knockout mice, supporting FXR-mediated antioxidative and anti-inflammatory mechanisms. |
Source: Tuo Wei, et al. “Unveiling the Therapeutic Potential of Suyin Detoxification Prescription in Diabetic Nephropathy: A Comprehensive Study Integrating Clinical Efficacy, Network Pharmacology, and Molecular Mechanisms.” Read article here.
