Summary:
In men with obesity, a 12-week High-Intensity Functional Training (HIFT) program significantly improved plasma adipo-myokine levels, body composition, and insulin sensitivity compared to placebo and supplement-only groups, though it was associated with no clinically significant side effects. Thylakoid supplementation showed modest, non-superior complementary effects on select myokines.
| PICO | Description |
|---|---|
| Population | Sixty men with obesity (mean age 27.6 ± 8.4 years; BMI 32.6 ± 2.6 kg/m²). |
| Intervention | 12 weeks of High-Intensity Functional Training (HIFT), 3 sessions/week (Borg scale: 15–17), with or without spinach thylakoid supplementation. |
| Comparison | Placebo group (PG), supplement-only group (SG), and HIFT + placebo (TPG) vs. HIFT + supplement (TSG). |
| Outcome | Both training groups (TPG and TSG) achieved significant improvements in adipo-myokines (e.g., decorin, follistatin), body composition, lipid profiles, and insulin resistance markers versus non-exercising groups (PG and SG). Thylakoid supplementation showed limited added benefit, suggesting exercise as the primary effective modulator. |
Source: Omid Razi, et al. “Adipo-Myokine Modulation in Obesity: Integrative Effects of Spinach Thylakoids and Functional Training in Men with Obesity: A Randomized Controlled Clinical Trial.” Read article here.
