Summary:
In male patients with Type 2 diabetes mellitus (T2DM), combined aerobic and resistance training (CT) significantly enhanced first- and second-phase insulin secretion (FPIS, SPIS) and glucose effectiveness (GE) compared to aerobic training (AT), resistance training (RT), and control groups, though it was associated with no reported adverse effects.
| PICO | Description |
|---|---|
| Population | Forty-five adult male patients with Type 2 diabetes mellitus (mean age: 55.24 ± 8.17 years; disease duration: 12.51 ± 6.46 years; HbA1c 7.1% ± 1.0%). |
| Intervention | Combined training (CT): 12-week program including progressive aerobic training (25-45 minutes at 70%-75% HRmax, 3×/week) and a modified resistance training regimen (1 set, 2×/week). |
| Comparison | Aerobic training alone (AT), resistance training alone (RT), and control group (no intervention). AT: 25-45 min at 70%-75% HRmax, 3×/week. RT: nine multijoint exercises, 2-3 sets, 8-12 reps, 3×/week. |
| Outcome | CT led to the greatest improvements: FPIS (+53.4%), SPIS (+38.9%), and GE (+12.8%) (all p ≤ 0.001). AT improved FPIS (+32.6%) and SPIS (+21.7%); RT improved FPIS (+28.5%), SPIS (+27.5%), and GE (+10.7%). Regression analysis identified baseline β-cell function, adiposity reduction, and glycemic improvement as predictors of FPIS change (R² = 0.537). |
Source: Piralaiy, Elaheh, et al. “Differential Effects of Aerobic, Resistance, and Combined Trainings on First- and Second-Phase Insulin Secretion and Glucose Effectiveness in Type 2 Diabetes: A Randomized Controlled Trial.” Read article here.
