Summary:
In adults with obesity, a hypocaloric ketogenic diet significantly reduced BMI, fat mass, fasting glucose, and total cholesterol compared to 16:8 time-restricted feeding and 5:2 alternate-day fasting, though it was associated with limited early orexin-A elevation compared to time-restricted eating.
| PICO | Description |
|---|---|
| Population | Adults (n=30) with obesity (BMI ≥ 30 kg/m2) enrolled in a 12-month randomized controlled dietary intervention trial. |
| Intervention | Hypocaloric ketogenic diet (KD) followed daily for 12 months with structured dietary logging and adherence monitoring. |
| Comparison | 16:8 time-restricted feeding (TRF16:8) and 5:2 alternate-day fasting (ADF5:2), both with equal duration and monitored adherence. |
| Outcome | The ketogenic diet led to the greatest sustained reductions in BMI, fat mass, fasting glucose, and cholesterol. Time-restricted eating showed the most consistent increase in Orexin-A levels, particularly early on. All interventions improved metabolic flexibility and reduced inflammation, and Orexin-A elevations were positively correlated with these effects. |
Source: Monda, Antonietta, et al. “Metabolic and Orexin-A Responses to Ketogenic Diet and Intermittent Fasting: A 12-Month Randomized Trial in Adults with Obesity.” Read article here.
