Summary:
In healthy adult women participating in two pooled randomized trials investigating thyroid function biomarkers during sleep restriction (SR), prolonged mild sleep restriction (SR) significantly reduced TSH levels compared to acute sleep (AS) or no sleep restriction, though it was associated with no significant changes in FT4 and FGF-21 levels. If sustained, these disruptions to the thyrotropic axis may elevate cardiometabolic risk in women.
| PICO | Description |
|---|---|
| Population | Healthy adult women participating in two pooled randomized trials investigating thyroid function biomarkers during sleep restriction (SR). |
| Intervention | Prolonged mild sleep restriction (SR). |
| Comparison | Acute sleep (AS) or no sleep restriction. |
| Outcome | Prolonged mild sleep restriction reduced TSH levels in women compared with AS. However, FT4 and FGF-21 levels remained unaffected. If sustained, these disruptions to the thyrotropic axis may elevate cardiometabolic risk in women. |
Source: Megan E Petrov, et al. “Impact of sleep restriction on biomarkers of thyroid function: Two pooled randomized trials.” Read article here.
