Summary:
In women with first trimester missed miscarriage, combination therapy of letrozole and misoprostol significantly improved complete miscarriage rates by day 7 compared to misoprostol-only or letrozole-only regimens, though it was associated with higher rates of bleeding and pain.
| PICO | Description |
|---|---|
| Population | Women diagnosed with first trimester missed miscarriage at Kasr Al-Aini Hospital, Cairo, Egypt (n = 225). |
| Intervention | Combination of letrozole followed by misoprostol (Group B). |
| Comparison | Misoprostol-only regimen (Group A) and letrozole-only regimen (Group C). |
| Outcome | The combination group had the highest rate of complete miscarriage by day 7 (76.0%), followed by letrozole-only (62.5%) and misoprostol-only (53.5%) (P = 0.0005). Early abortion by day 4 was most common in the combination group (68.4%). While the combination therapy led to the highest adverse event rates, particularly bleeding (85.3%) and pain (92.0%), severe events were rare. |
Source: Mohamed Fikry Yousef, et al. “Efficacy and Safety of Letrozole, Misoprostol and Their Combination in First Trimester Missed Miscarriage: A Randomised Clinical Trial.” Read article here.
