Summary:
In patients with persistent and recalcitrant diabetic foot ulcers (DFUs),adjunctive treatment with a full-thickness decellularised placental membrane allograft (FT-DPM) significantly improved wound healing rates and ulcer closure compared to standard of care alone (debridement and moist wound therapy),
though it was associated with some local adverse events including mild to moderate wound site irritation.
| PICO | Description |
|---|---|
| Population | Adults with persistent and recalcitrant diabetic foot ulcers (DFUs) refractory to conventional treatment. |
| Intervention | Application of full-thickness decellularised placental membrane allograft (FT-DPM) to the wound bed post-debridement, left in place for 5-9 days. |
| Comparison | Standard of care (SoC) alone, including wound debridement and moist wound therapy without allograft application. |
| Outcome | FT-DPM significantly increased rates of ulcer closure and accelerated healing time compared to SoC alone; mild to moderate wound site irritation was the main adverse event reported. |
Source: Reyzelman, Alexander M, et al. “Efficacy of a full-thickness decellularised placental membrane allograft compared to standard of care in diabetic foot ulcers: a prospective, randomised controlled trial.” Read article here.
