Summary:
In women with polycystic ovary syndrome undergoing in vitro fertilisation, vitamin D supplementation (4000 IU/day for up to 90 days) did not significantly improve live birth rates after the first embryo transfer compared to placebo, though it was associated with increased serum 25-hydroxyvitamin D levels without notable adverse effects.
| PICO | Description |
|---|---|
| Population | Women diagnosed with polycystic ovary syndrome (PCOS) undergoing in vitro fertilisation treatment. |
| Intervention | Vitamin D supplementation at a dose of 4000 IU per day for up to 90 days prior to IVF. |
| Comparison | Placebo administration with no vitamin D supplementation. |
| Outcome | Vitamin D supplementation increased serum 25-hydroxyvitamin D concentrations but did not significantly improve live birth rates post-first embryo transfer. No significant adverse side effects were reported. |
Source: Kai-Lun Hu, et al. “Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.” Read article here.
