Summary:
In adults at risk of type 2 diabetes, intermittent fasting plus early time-restricted eating (iTRE) and calorie restriction (CR) significantly reduced inflammatory markers such as CRP and TNF-α over six months compared to standard care (SC), though it was associated with no differential effects in adipose tissue gene expression or systemic inflammation between the interventions.
| PICO | Description |
|---|---|
| Population | Adults (N = 209) with a mean BMI of 34.8 ± 4.7 kg/m² at risk of developing type 2 diabetes. |
| Intervention | Intermittent fasting with early time-restricted eating (iTRE): 30% energy intake between 08:00 and 12:00 on 3 days/week; and Calorie Restriction (CR): 30% energy reduction daily, for 6 months. |
| Comparison | Standard care (SC) with no specific dietary intervention. |
| Outcome | Both iTRE and CR led to greater weight loss than SC. Systemic inflammatory markers CRP (-1.36 ± 0.47 mg/dL, p<0.001) and TNF-α (-0.082 ± 0.03 pg/mL, p=0.025) decreased across groups with no significant differences between iTRE and CR. No changes were observed in inflammatory gene expression in adipose tissue. |
Source: Laurent Turner, et al. “Impact of Achieved Weight Loss by Intermittent Fasting Plus Early Time-Restricted Eating and Calorie Restriction on Systemic and Adipose Tissue Markers of Inflammation in Adults at Risk of Type 2 Diabetes: An Exploratory Sub-Study.” Read article here.
