Summary:
In older Australian adults aged 60–84 years, monthly supplementation with 60,000 IU of vitamin D3 did not significantly reduce the incidence of placebo group participants, though it was associated with no notable side effects.
| PICO | Description |
|---|---|
| Population | Community-dwelling Australians aged 60–84 years, mostly vitamin D-replete at baseline. |
| Intervention | Monthly oral supplementation with 60,000 IU of vitamin D3. |
| Comparison | Placebo group receiving no active vitamin D supplementation. |
| Outcome | No significant effect on incidence of hypertension (HR 1.00; 95% CI 0.93–1.08), hypercholesterolemia (HR 1.05; 95% CI 0.97–1.13), or type 2 diabetes (HR 0.97; 95% CI 0.84–1.12) over a median 4.6-year follow-up. |
Source: Briony L Duarte Romero, et al. “Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults—Results from the Randomized Controlled D-Health Trial.” Read article here.
