Summary:
In people with chronic breathlessness and Chronic Obstructive Pulmonary Disease (COPD), regular low-dose morphine significantly improved diurnal cortisol slope and reduced subjective breathlessness compared to no morphine intervention, though it was associated with minor gastrointestinal side effects.
| PICO | Description |
|---|---|
| Population | People with chronic breathlessness and Chronic Obstructive Pulmonary Disease (COPD). |
| Intervention | Regular low-dose morphine (dosage not specified in the summary). |
| Comparison | Control group with no morphine intervention. |
| Outcome | Low-dose morphine resulted in significant improvement of diurnal cortisol slope (steeper slope) and reduced subjective breathlessness. Minor gastrointestinal side effects were noted but were manageable in clinical settings. |
Source: Diana H Ferreira, et al. “The longitudinal impact of low-dose morphine on diurnal cortisol profiles in people with chronic breathlessness and chronic obstructive pulmonary disease (COPD): an exploratory study.” Read article here.
