Summary:
In healthy adults, intradermal morphine significantly induced itch and increased neurogenic inflammation compared to controls (placebo and mechanical stimulation), though it was associated with mild localized discomfort.
| PICO | Description |
|---|---|
| Population | Twenty-four healthy adult volunteers. |
| Intervention | Intradermal injection of morphine to the volar forearm. |
| Comparison | Placebo injection and experimental mechanical stimulation. |
| Outcome | Intradermal morphine induced significant itch with histaminergic and non-histaminergic components, along with increased neurogenic inflammation. Responses to induced itch were enhanced, though mild discomfort was reported at the injection site. |
Source: Lo Vecchio, Silvia, et al. “Effect of Intradermal Morphine on Histaminergic and Non-Histaminergic Itch: A Randomised, Single-Blinded, Human Study.” Read article here.
