Summary:
In participants with prediabetes and type 2 diabetes, circulating Gremlin 2 (Grem2) levels significantly decreased and were associated with impaired β-cell function compared to those with normal glucose tolerance, though it was associated with partial restoration through antidiabetic interventions.
| PICO | Description |
|---|---|
| Population | Participants with prediabetes and type 2 diabetes (T2D), compared to those with normal glucose tolerance. |
| Intervention | Measurement of circulating Gremlin 2 (Grem2) levels and its modulation through antidiabetic interventions. |
| Comparison | Comparison of circulating Grem2 levels between participants with normal glucose tolerance, prediabetes, and T2D. |
| Outcome | Reduced circulating Grem2 levels were associated with impaired β-cell function in T2D patients. Antidiabetic interventions showed partial restoration of Grem2 levels, indicating potential for β-cell function improvement. |
Source: Mengshan Ni, et al. “Association Between Circulating Gremlin 2 and β-Cell Function Among Participants With Prediabetes and Type 2 Diabetes.” Read article here.
