Summary:
In postmenopausal women with overweight or obesity, high-dose green tea extract (GTE) supplementation (843 ± 44 mg EGCG/day) did not significantly reduce inflammatory cytokines compared to placebo over a 12-month period, and it was not associated with notable side effects.
| PICO | Description |
|---|---|
| Population | Postmenopausal women with overweight or obesity, participating in the Minnesota Green Tea Trial (n = 97). |
| Intervention | Daily supplementation with high-dose green tea extract containing 843 ± 44 mg epigallocatechin gallate (EGCG) for 12 months. |
| Comparison | Placebo group receiving an identical capsule without active ingredients for the same duration. |
| Outcome | No statistically significant differences were observed between GTE and placebo groups for changes in serum CRP (p = 0.24), IL-6 (p = 0.59), or TNF-α (p = 0.36) over 12 months. COMT genotype did not modify these effects. |
Source: Cunningham, Anca, et al. “Effects of Green Tea Extract Supplementation on Inflammatory Cytokines Among Postmenopausal Women with Overweight or Obesity—A Secondary Analysis of a Randomized Controlled Trial.” Read article here.
