Summary:
In obese patients with type 2 diabetes mellitus and liver steatosis, curcumin supplementation
significantly attenuated liver steatosis by reducing oxidative stress and inflammation compared to placebo, though it was associated with mild gastrointestinal side effects.
| PICO | Description |
|---|---|
| Population | Obese adults diagnosed with type 2 diabetes mellitus presenting with liver steatosis. |
| Intervention | Curcumin supplementation administered over 12 months (exact dosing as per trial protocol). |
| Comparison | Placebo control group receiving no active curcumin treatment. |
| Outcome | Curcumin significantly reduced liver fat accumulation and markers of oxidative stress and inflammation compared to placebo. Mild gastrointestinal side effects were noted but no severe adverse events occurred. |
Source: Yaikwawong, Metha, et al. “Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.” Read article here.
