Summary:
In individuals at increased risk of gestational diabetes mellitus (GDM) planning pregnancy, a preconception lifestyle intervention involving time-restricted eating and exercise did not significantly reduce neonatal birth weight or body composition outcomes compared to standard care controls, though it was associated with no adverse effects.
| PICO | Description |
|---|---|
| Population | Individuals (N=167) at elevated risk for gestational diabetes mellitus (GDM), planning pregnancy, and enrolled in the BEFORE THE BEGINNING randomized controlled trial. |
| Intervention | A lifestyle program initiated before conception and maintained during pregnancy, including time-restricted eating (≤10 h/day, ≥5 days/week) and physical activity targeting ≥100 weekly Personal Activity Intelligence (PAI) points. |
| Comparison | Standard care control group without structured lifestyle intervention. |
| Outcome | No statistically significant differences were observed for the primary outcome of infants with birth weight > 4.0 kg (21% intervention vs. 28% control; p = 0.367) or for other neonatal, birth-related, and early postnatal body composition measures. |
Source: Md Abu Jafar Sujan, et al. “Neonatal Outcomes Following a Preconception Lifestyle Intervention in People at Risk of Gestational Diabetes: Secondary Findings from the BEFORE THE BEGINNING Randomized Controlled Trial.” Read article here.
