Summary:
In Chinese middle-aged and elderly adults with prediabetes or early diabetes, purified anthocyanins supplementation (160, 320, 640 mg/day) did not significantly improve arterial stiffness or cardiovascular risk factors compared to placebo, and was not associated with notable side effects.
| PICO | Description |
|---|---|
| Population | Chinese middle-aged and elderly adults with prediabetes or early-stage diabetes (dysglycemia). |
| Intervention | Daily supplementation with purified anthocyanins at doses of 160 mg, 320 mg, and 640 mg over a 12-week period. |
| Comparison | Placebo control group receiving no active anthocyanins. |
| Outcome | No statistically significant improvements in arterial stiffness (measured by baPWV), ankle-brachial index, four-limb blood pressures, or composite cardiovascular risk factors across any dosage compared to placebo. No notable adverse effects reported. |
Source: Zhaomin Liu, et al. “Purified Anthocyanins Indicated No Significant Effect on Arterial Stiffness, Four-Limb Blood Pressures and Cardiovascular Risk—A 12-Week Dose-Response Trial in Chinese Middle-Aged and Elderly Adults with Hyperglycemia.” Read article here.
