Summary:
In patients with mild to moderate anaphylaxis, corticosteroid administration post-eventm did not significantly reduce the recurrence of anaphylaxis compared to no corticosteroid treatment, though it was associated with potential over-treatment and no reduction in recurrence rates. Results suggest against its routine usage in emergency department settings without a clinical rationale.
| PICO | Description |
|---|---|
| Population | Patients with mild to moderate anaphylaxis treated in the emergency department (ED). |
| Intervention | Administration of corticosteroid post-anaphylaxis episode to prevent recurrence. |
| Comparison | No corticosteroid administration post-anaphylaxis treatment. |
| Outcome | Corticosteroid use did not significantly reduce recurrence risk of anaphylaxis. Results suggest uncommon recurrence post-ED treatment and a high number needed to treat, questioning the necessity of routine corticosteroid usage. |
Source: Rafah Al Sayyed, et al. “Randomized blinded pilot trial of corticosteroid after mild-moderate anaphylaxis to prevent recurrence.” Read article here.
