Summary:
In adults with type 2 diabetes and β-cell dysfunction, co-supplementation with live multistrain probiotics and omega-3 polyunsaturated fatty acids (PUFAs) significantly improved β-cell function and insulin sensitivity compared to placebo treatment, though it was associated with no reported adverse effects.
| PICO | Description |
|---|---|
| Population | Adults diagnosed with type 2 diabetes exhibiting β-cell dysfunction (%B < 50%) and receiving insulin therapy (alone or combined with oral antidiabetic drugs). |
| Intervention | Co-supplementation of live multistrain probiotic with omega-3 PUFAs. |
| Comparison | Placebo group with no active supplementation. |
| Outcome | The intervention showed a marginally significant increase in β-cell function (%B from 42.2 ± 15.4 to 62.21 ± 33.98; p=0.049), improved insulin sensitivity, reduced fasting plasma glucose, and lowered TNF-α levels. However, adjusted ANCOVA revealed no statistically significant difference versus placebo for β-cell function. |
Source: Maryana Savytska, et al. “Efficacy of probiotic co-supplementation with omega-3 PUFAs on pancreatic beta-cell function in type 2 diabetes.” Read article here.
