Summary:
In women with type 1 diabetes during pregnancy, metformin significantly reduced prandial insulin use and improved weight control compared to placebo, though it was associated with no significant effect on total insulin use.
| PICO | Description |
|---|---|
| Population | Pregnant women with type 1 diabetes. |
| Intervention | Metformin as an adjunct for glycemic control. |
| Comparison | Placebo. |
| Outcome | Metformin was associated with reduced prandial insulin change and weight gain control, particularly in insulin-resistant subgroups. However, no impact was observed on total insulin change. These findings support further research on the role of metformin during pregnancy in type 1 diabetes. |
Source: Juuma, Elina, et al. “The Effect of Metformin on Insulin Requirement, Glycaemic Control and Weight Gain in Type 1 Diabetes During Pregnancy—a Randomised, Placebo-Controlled Multicentre Study.” Read article here.
