Summary:
In sedentary obese adult men (BMI ≥ 30 kg/m²), 12 weeks of combined interval resistance and progressive aerobic training supplemented with fisetin (200 mg/day) significantly reduced pro-inflammatory adipokines (asprosin: −60.71%; MCP-1: −46.50%), improved adiponectin (+27.67%), leptin, and lipid profiles compared to placebo, exercise-alone, or fisetin-alone groups, though it was associated with no reported adverse effects.
| PICO | Description |
|---|---|
| Population | Sixty sedentary adult men with obesity (BMI ≥ 30 kg/m²) who were randomly assigned to intervention or control groups. |
| Intervention | Combined interval resistance-aerobic exercise (3× weekly; 60% 1RM resistance and 50–70% HRmax aerobic activity) plus fisetin supplementation at 200 mg/day for 12 weeks. |
| Comparison | Placebo group (no exercise or fisetin), fisetin-only group (200 mg/day), and exercise-only group (same protocol without fisetin). |
| Outcome | The combined training plus fisetin group showed the greatest reductions in asprosin and MCP-1, increased adiponectin, improved lipid profile (decreased LDL-C, TG, TC; increased HDL-C), and reduced BMI relative to all other groups. No adverse events were reported. |
Source: Alipour, Mehran, et al. “The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.” Read article here.
