Summary:
In adolescents and young adults with type 1 diabetes, a low-carbohydrate (LC) diet did not significantly affect bone turnover markers compared to a Mediterranean (MED) diet, though it was associated with reduced calcium and magnesium intake and a significant decline in alkaline phosphatase levels.
| PICO | Description |
|---|---|
| Population | Adolescents and young adults aged 12–21 years with type 1 diabetes. |
| Intervention | Low-carbohydrate (LC) diet intervention for 24 weeks (median carbohydrate intake: 86 g/day). |
| Comparison | Mediterranean (MED) diet over the same 24-week period (median carbohydrate intake: 130 g/day). |
| Outcome | No statistically significant changes in bone turnover markers (CTX, P1NP) were observed in either group. LC group had significantly lower alkaline phosphatase levels (p = 0.009) and reduced calcium and magnesium intakes, although these did not remain significant after false-discovery rate correction. |
Source: Levran, Neriya, et al. “Bone Turnover Markers (CTX and P1NP) Following Low-Carbohydrate and Mediterranean Diet Interventions in Adolescents and Young Adults with Type 1 Diabetes.” Read article here.
