Summary:
In semiprofessional male ultramarathon runners, a single high-dose vitamin D3 supplementation (150,000 IU cholecalciferol) significantly enhanced bone formation and attenuated bone resorption compared to placebo administered 24 hours pre-race, though it was associated with no reported adverse effects.
| PICO | Description |
|---|---|
| Population | 35 semiprofessional male ultramarathon runners participating in a mountain ultramarathon. |
| Intervention | A single oral dose of 150,000 IU vitamin D3 (cholecalciferol) in vegetable oil given 24 hours before the ultramarathon. |
| Comparison | Placebo solution administered 24 hours prior to the ultramarathon in 19 participants. |
| Outcome | Supplemented group showed greater increases in 25(OH)D3 serum levels (147.01% vs 84.71%), elevated bone formation marker PINP post-run, and lower levels of bone resorption markers (CTX, PTH, sclerostin, procalcitonin) 24 hours post-run compared to placebo. No adverse effects were noted. |
Source: Błażej Stankiewicz, et al. “Single high-dose vitamin D supplementation impacts ultramarathon-induced changes in serum levels of bone turnover markers: a double-blind randomized controlled trial.” Read article here.
