Summary:
In families of individuals with premature coronary heart disease, a family-based structured lifestyle modification intervention significantly improved quality-adjusted life years (QALYs) and reduced key cardiovascular risk factors compared to usual care involving one-time counselling and annual screening, though it was associated with modest incremental costs.
| PICO | Description |
|---|---|
| Population | Adults (>18 years), including first-degree relatives and spouses of individuals with premature coronary heart disease. |
| Intervention | A comprehensive package of structured lifestyle interventions including risk factor screening, behavior change support by non-physician health workers, linkage to primary care, and active follow-up over two years. |
| Comparison | Usual care consisting of one-time lifestyle counselling and annual cardiovascular risk factor screening without structured follow-up. |
| Outcome | The intervention resulted in an incremental QALY gain of 0.014 at an incremental cost of Int$157.5 per person, yielding an ICER of Int$11,352 per QALY gained. Significant reductions were observed in systolic blood pressure, fasting plasma glucose, HbA1c, cholesterol, and waist circumference. The intervention was found to be cost-effective under a threshold of three times GDP per capita. |
Source: Ashis Samuel John, et al. “Within-Trial Cost-Effectiveness Analysis of a Family-Based Structured Lifestyle Modification Intervention Program for Cardiovascular Risk Reduction: Results from the PROLIFIC Trial.” Read article here.
